Author: Sullivan, Meghan; Kaur, Kaval; Pauli, Noel; Wilson, Patrick C.
Title: Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses Document date: 2011_8_1
ID: qh6ybagu_1
Snippet: Studying the molecular arms race that characterizes our constant fight against pathogens has revealed a powerful source of therapeutics using an obvious and widely available resource: our own immune response. In particular, it is the therapeutic potential of monoclonal antibodies (mAbs)-highly specific, continuously generating antibodies derived from a single B cell clone that target only a single site (epitope) on a single antigenthat offers a l.....
Document: Studying the molecular arms race that characterizes our constant fight against pathogens has revealed a powerful source of therapeutics using an obvious and widely available resource: our own immune response. In particular, it is the therapeutic potential of monoclonal antibodies (mAbs)-highly specific, continuously generating antibodies derived from a single B cell clone that target only a single site (epitope) on a single antigenthat offers a lot of this potential. These are exciting times in monoclonal antibody research. The steady stream of technological advances is, if anything, accelerating in the 21 st century, knocking down obstacles in the process. New applications are wide ranging-from finding the Achilles heel of pathogens and elucidating autoimmune disease, to treating infections in patients. The latest round of developments allows us to hope that they may be used in the clinic to kill cancer cells and eradicate pathogens such as influenza.
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