Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells

Li, Hai; Wang, Fengjie; Han, Zongxi; Gao, Qi; Li, Huixin; Shao, Yuhao; Sun, Nana; Liu, Shengwang

The proto-oncogene tyrosine-protein kinase Src (Src) was originally isolated from a chicken sarcoma, and it was the first oncogene to be identified (19) . It is well-known that Src is an important factor for a wide range of biological processes, such as cell proliferation, adhesion, angiogenesis, organization of the cell skeleton, cell division, and cell death (20) (21) (22) (23) (24) . The tyrosine kinase focal adhesion kinase (FAK) has been shown to be required for integrin-stimulated cell migration and focal adhesion formation (25) (26) (27) , the disruption of which triggers apoptosis (28, 29) . The interaction between Src and FAK has been shown to promote the entry of human herpes simplex virus 1 (HSV-1) into target cells (30, 31) . However, to the best of our knowledge, the effects of host Src on host cell death during human or animal herpesvirus infections have never been reported, despite the fact that Src is considered to be both a survival factor (32, 33) and a death factor (33) (34) (35) .