Author: Cleemput, Sara; Dumon, Wim; Fonseca, Vagner; Karim, Wasim Abdool; Giovanetti, Marta; Alcantara, Luiz Carlos; Deforche, Koen; de Oliveira, Tulio
Title: Genome Detective Coronavirus Typing Tool for rapid identification and characterization of novel coronavirus genomes Document date: 2020_2_28
ID: st5idleq_7
Snippet: The tool uses a novel and dynamic aligner, AGA, to allow submitted sequences to be queried against reference genomes, using both nucleotide and amino acid similarity scores. This allows accurate identification of other coronavirus species and the tracking of new viral mutations as the outbreak expands globally. It also performs detailed analysis of the coding regions and proteins. Moreover, it can easily be updated to add new phylogenetic cluster.....
Document: The tool uses a novel and dynamic aligner, AGA, to allow submitted sequences to be queried against reference genomes, using both nucleotide and amino acid similarity scores. This allows accurate identification of other coronavirus species and the tracking of new viral mutations as the outbreak expands globally. It also performs detailed analysis of the coding regions and proteins. Moreover, it can easily be updated to add new phylogenetic clusters if new outbreaks arise or if the classification nomenclature changes. The tool has been able to correctly classify all the recently released SARS-CoV-2 genomes, as well as all the 2002-2003 SARS outbreak sequences
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