Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells

Li, Hai; Wang, Fengjie; Han, Zongxi; Gao, Qi; Li, Huixin; Shao, Yuhao; Sun, Nana; Liu, Shengwang

notation (subset GOTERM_CC_FAT, GOTERM_BP_FAT, and GOTERM_MF_FAT) (45) with a P value of Ͻ0.05. The five functions from each subset showing the greatest differential gene expression are listed in Fig. 2C . Cellular component analysis revealed that these differentially expressed genes were significantly enriched in those involved in the extracellular region and the plasma membrane (Fig. 2C) . Meanwhile, after ILTV infection the major biological processes controlled by genes that were differentially expressed were the regulation of cell proliferation, the enzyme-linked receptor protein signaling pathway, skeletal system development, and embryonic organ development (Fig. 2C) . The molecular functions of these differentially expressed genes appeared to be focused toward serine peptidase activity (Fig. 2C ).