Author: Li, Hai; Wang, Fengjie; Han, Zongxi; Gao, Qi; Li, Huixin; Shao, Yuhao; Sun, Nana; Liu, Shengwang
Title: Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells Document date: 2015_12_17
ID: qwrdr92h_34
Snippet: A pathway analysis of the subgroup of differentially expressed genes most closely connected to Src (see Fig. S3A in the supplemental material) indicated that the integrin signaling, focal adhesion, and adherens junction pathways were directly regulated by Src (see Fig. S3B in the supplemental material). Despite being involved in a wide range of biological processes (20) (21) (22) (23) (24) , it is well-known that Src mediates integrin-focal ad- h.....
Document: A pathway analysis of the subgroup of differentially expressed genes most closely connected to Src (see Fig. S3A in the supplemental material) indicated that the integrin signaling, focal adhesion, and adherens junction pathways were directly regulated by Src (see Fig. S3B in the supplemental material). Despite being involved in a wide range of biological processes (20) (21) (22) (23) (24) , it is well-known that Src mediates integrin-focal ad- hesion signal transduction by interacting with FAK (27, 49) . Thus, we hypothesized that activated FAK is required for Src activation and the subsequent prolonged survival of LMH cells following ILTV infection.
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