Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway Document date: 2016_11_21
ID: w5m23ikh_26
Snippet: As it was unclear whether this envelope protein increased MAN1C1 expression via a direct or indirect effect, we further investigated the exact mechanisms involved in HBV-induced MAN1C1 expression. We examined whether the HBV envelope protein activated the PPARγ pathway to increase the expression of MAN1C1 protein. However, we found that inhibition of the PPARγ pathway with GW9662 did not affect the HBV envelope protein-induced upregulation of M.....
Document: As it was unclear whether this envelope protein increased MAN1C1 expression via a direct or indirect effect, we further investigated the exact mechanisms involved in HBV-induced MAN1C1 expression. We examined whether the HBV envelope protein activated the PPARγ pathway to increase the expression of MAN1C1 protein. However, we found that inhibition of the PPARγ pathway with GW9662 did not affect the HBV envelope protein-induced upregulation of MAN1C1 expression. On the other hand, when the PPARα pathway was inhibited with MK886, the envelope protein could not upregulate MAN1C1 expression. Our results indicate that MAN1C1 expression is associated with the PPARα pathway, whereas previous studies have shown that MAN1C1 expression in endothelial cells is associated with the PPARγ pathway [14] . We
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