Author: Wang, Huihui; Song, Hyo; Pham, Anha V.; Cooper, Laurence J.; Schulze, Janika J.; Olek, Sven; Tran, Dat Q.
Title: Human LAP(+)GARP(+)FOXP3(+) regulatory T cells attenuate xenogeneic graft versus host disease Document date: 2019_4_12
ID: rudsvyqd_40
Snippet: Overall, our study provides greater characterizations of LAP + Tregs to support their therapeutic application for GVHD and other autoimmune conditions. Regardless of the methods and strategies used to expand Tregs, co-expansion of other cells, particularly FOXP3 + nonTregs, is almost inevitable. With the application of LAP or GARP repurification, a highly purified, TSDR demethylated Treg population can be achieved which maintains diversity and fu.....
Document: Overall, our study provides greater characterizations of LAP + Tregs to support their therapeutic application for GVHD and other autoimmune conditions. Regardless of the methods and strategies used to expand Tregs, co-expansion of other cells, particularly FOXP3 + nonTregs, is almost inevitable. With the application of LAP or GARP repurification, a highly purified, TSDR demethylated Treg population can be achieved which maintains diversity and functionality. The next step is to demonstrate their safety, stability and functionality in a human clinical trial.
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