GRASP depletion–mediated Golgi destruction decreases cell adhesion and migration via the reduction of a5ß1 integrin

Ahat, Erpan; Xiang, Yi; Zhang, Xiaoyan; Bekier, Michael E.; Wang, Yanzhuang

observation of increased protein synthesis in this study could also be attributed to the increased demand of the cells for more proteins with increased trafficking and cell growth. It has been demonstrated that, at the onset of mitosis, phosphorylation of GRASPs and golgins by mitotic kinases results in Golgi disassembly, which is required for cell cycle progression (Jesch et al., 2001; Sutterlin et al., 2002; Duran et al., 2008; Xiang and Wang, 2010; Guizzunti and Seemann, 2016) , and GRASP depletion accelerates cell cycle progression (Tang et al., 2010) . It is conceivable that cells with unstacked Golgi grow faster, as protein synthesis and cargo transport are enhanced. Some signaling pathways may be selectively activated or inhibited to control the synthesis of different proteins. Exploiting the underlying mechanism will be a future direction of this study.