Title: Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment Document date: 1992_9_2
ID: qasgn7s9_38
Snippet: The relationship of the localization of the intracellular pool of HBsAg to that of soluble ER proteins was studied by indirect double immunofluorescence microscopy. Although a large fraction of the HBsAg (Fig. 3 b) colocalizes with PDI ( Fig. 3 a) , there are localized HBsAg rich regions which appear to exclude PDI. A similar pattern is revealed with other ER markers such as BiP. All regions that show BiP staining (Fig. 3 c) also show staining fo.....
Document: The relationship of the localization of the intracellular pool of HBsAg to that of soluble ER proteins was studied by indirect double immunofluorescence microscopy. Although a large fraction of the HBsAg (Fig. 3 b) colocalizes with PDI ( Fig. 3 a) , there are localized HBsAg rich regions which appear to exclude PDI. A similar pattern is revealed with other ER markers such as BiP. All regions that show BiP staining (Fig. 3 c) also show staining for HBsAg but localized regions that are enriched in HBsAg (Fig. 3 d) appear to exclude the soluble ER protein. The identity of staining of anti-KXsKDEL with that of the other ER markers in SV24 cells (Fig. 2) suggests that the other major KDEL-proteins behave similarly.
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