Selected article for: "activation pathway and high expression"
Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway
  • Document date: 2016_11_21
    • ID: w5m23ikh_38
    Snippet: Tumor necrosis factor-α has been shown to downregulate the expression of MAN1C1 to increase the expression of high-mannose type proteoglycans, and this can be reversed by the activation of the PPAR signaling pathway. Based on the results of these previous studies, the authors hypothesized that HBV could promote the demannosylation of the viral protein by increasing the expression of α-mannosidase I in the host cells......
    Document: Tumor necrosis factor-α has been shown to downregulate the expression of MAN1C1 to increase the expression of high-mannose type proteoglycans, and this can be reversed by the activation of the PPAR signaling pathway. Based on the results of these previous studies, the authors hypothesized that HBV could promote the demannosylation of the viral protein by increasing the expression of α-mannosidase I in the host cells.

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