Author: Zeng, Zhengyang; Zhang, Runhong; Hong, Wei; Cheng, Yuting; Wang, Huijuan; Lang, Yange; Ji, Zhenglin; Wu, Yingliang; Li, Wenxin; Xie, Youli; Cao, Zhijian
Title: Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1 Document date: 2018_1_1
ID: zilqyfjl_52
Snippet: To further investigate the inhibitory activity of Eval418 against HSV-1, Vero cells were treated with Eval418 over a series of concentrations during the viral attachment or entry steps. Similar to viral inactivation, the inhibitory activity against viral attachment was also dose-dependent, and the IC50 was 3.70 μg/mL (Figure 4d ). Eval418 also showed weak inhibition of viral entry. The inhibition rate was only 23.08% at 10 µg/mL (Figure 4e ). T.....
Document: To further investigate the inhibitory activity of Eval418 against HSV-1, Vero cells were treated with Eval418 over a series of concentrations during the viral attachment or entry steps. Similar to viral inactivation, the inhibitory activity against viral attachment was also dose-dependent, and the IC50 was 3.70 μg/mL (Figure 4d ). Eval418 also showed weak inhibition of viral entry. The inhibition rate was only 23.08% at 10 µg/mL (Figure 4e ). Therefore, Eval418 showed a dose-dependent and time-dependent inhibition against HSV-1 plaque formation during the viral inactivation step and a dose-dependent inhibition of viral attachment. In addition, compared with its CC50 to Vero cells, the selection index (SI) of Eval418 was 27.62 during the viral inactivation step and 18.51 during the viral attachment step (Table 1) .
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