Author: Sullivan, Meghan; Kaur, Kaval; Pauli, Noel; Wilson, Patrick C.
Title: Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses Document date: 2011_8_1
ID: qh6ybagu_4
Snippet: Most current antibody-based therapeutics were originally generated in rodents or in the laboratory with powerful technologies such as phage display-a method for the random generation of novel antibodies that relies on random pairing of antibody genes and antigen screening to select for those monoclonal antibodies with specificities of interest. However, potentially severe reactions to nonhuman sources of antibodies can occur. Thus, reliable sourc.....
Document: Most current antibody-based therapeutics were originally generated in rodents or in the laboratory with powerful technologies such as phage display-a method for the random generation of novel antibodies that relies on random pairing of antibody genes and antigen screening to select for those monoclonal antibodies with specificities of interest. However, potentially severe reactions to nonhuman sources of antibodies can occur. Thus, reliable sources of human monoclonal antibodies were sought to not only overcome deleterious side effects but also increase the chances of finding clinically relevant antibodies to antigens of interest. Figure 1 provides a timeline of critical advances in monoclonal antibody technologies as detailed in the following sections.
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