Selected article for: "cell function and chronic infection"
Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway
  • Document date: 2016_11_21
    • ID: w5m23ikh_42
    Snippet: HBV infection is the most common chronic viral infection worldwide. Because of insufficient immune response, some HBV-infected patients will develop chronic hepatitis and possibly liver cirrhosis and hepatocellular carcinoma. In the present study, the authors aimed to explore one of the mechanisms able to impair dendritic cell function in patients suffering from chronic hepatitis B; they hypothesized that HBV could promote the demannosylation of .....
    Document: HBV infection is the most common chronic viral infection worldwide. Because of insufficient immune response, some HBV-infected patients will develop chronic hepatitis and possibly liver cirrhosis and hepatocellular carcinoma. In the present study, the authors aimed to explore one of the mechanisms able to impair dendritic cell function in patients suffering from chronic hepatitis B; they hypothesized that HBV could promote the demannosylation of HBV glycoprotein coat by increasing the expression of α-mannosidase 1 allowing HBV to escape from host immunity.

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