Author: Lang, Dorothy M.; Zemla, A. T.; Zhou, C. L. Ecale
Title: Highly similar structural frames link the template tunnel and NTP entry tunnel to the exterior surface in RNA-dependent RNA polymerases Document date: 2012_12_25
ID: s90geszi_141
Snippet: The traditional perspective of the relationship between the amino acid sequence of a protein and its tertiary structure has been that sequence determines structure. Under this premise, sequence-based evolutionary studies and phylogeny would inherently incorporate structure. In this study of RdRps, we demonstrated that structure accommodates substantial sequence variability, and that highly diverse sequences can generate highly similar tertiary st.....
Document: The traditional perspective of the relationship between the amino acid sequence of a protein and its tertiary structure has been that sequence determines structure. Under this premise, sequence-based evolutionary studies and phylogeny would inherently incorporate structure. In this study of RdRps, we demonstrated that structure accommodates substantial sequence variability, and that highly diverse sequences can generate highly similar tertiary structures. Structure-based phylogeny may provide new perspectives of protein evolution.
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