Author: Lippens, Carla; Duraes, Fernanda V.; Dubrot, Juan; Brighouse, Dale; Lacroix, Mathilde; Irla, Magali; Aubry-Lachainaye, Jean-Pierre; Reith, Walter; Mandl, Judith N.; Hugues, Stéphanie
Title: IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity Document date: 2016_12_23
ID: sl8148ap_6
Snippet: Here we show that in steady-state lymph nodes (LNs), IDO is highly expressed by pDCs compared to other LN resident cells. We further established that IDO expression is positively regulated in steady-state pDCs following MHCII-mediated interactions with Tregs. During autoimmune disorders, such as EAE, IDO expression by MHCII competent pDCs is mandatory to confer suppressive functions to pDC-induced Tregs. IDO-competent Ag-presenting pDCs promote T.....
Document: Here we show that in steady-state lymph nodes (LNs), IDO is highly expressed by pDCs compared to other LN resident cells. We further established that IDO expression is positively regulated in steady-state pDCs following MHCII-mediated interactions with Tregs. During autoimmune disorders, such as EAE, IDO expression by MHCII competent pDCs is mandatory to confer suppressive functions to pDC-induced Tregs. IDO-competent Ag-presenting pDCs promote Tregs that inhibit autoimmune effector T cell responses in LNs, resulting in reduced disease severity. Therefore, we have identified a bidirectional interaction between pDCs and Tregs that favours self-tolerance.
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