Author: Sullivan, Meghan; Kaur, Kaval; Pauli, Noel; Wilson, Patrick C.
Title: Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses Document date: 2011_8_1
ID: qh6ybagu_8
Snippet: animals, was the production of primatized monoclonal antibodies. These monoclonal antibodies are raised in primates and engineered to express human structural domains. Since humans and monkeys are more closely related, the antibodies that pass autoreactivity checkpoints in monkeys will presumably be less cross-reactive to human proteins than antibodies raised in rodents [11] . Even with human monoclonal antibodies, genetic variability between the.....
Document: animals, was the production of primatized monoclonal antibodies. These monoclonal antibodies are raised in primates and engineered to express human structural domains. Since humans and monkeys are more closely related, the antibodies that pass autoreactivity checkpoints in monkeys will presumably be less cross-reactive to human proteins than antibodies raised in rodents [11] . Even with human monoclonal antibodies, genetic variability between the person who was the source of the antibody and the recipient (i.e., differences in blood or HLA type) may lead to complications due to the individual selective environment in which the B cell was formed. Therefore, while the use of human antibodies overcomes several complications and will likely expedite development of monoclonal antibody therapeutics, it is appreciated that all monoclonal antibody therapeutics must first be vetted for safety.
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