Selected article for: "HBV glycoprotein coat and present study"
Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway
  • Document date: 2016_11_21
    • ID: w5m23ikh_2
    Snippet: Peroxisome proliferator activated-receptors (PPARs), a group of ligand-activated nuclear transcription factors, may be involved in α-mannosidase expression during HBV infection. Indeed, tumor necrosis factor-α (TNF-α) has been shown to downregulate the expression of MAN1C1 to increase the expression of high-mannose type proteoglycans, and this can be reversed by the activation of the PPAR signaling pathway [14] . Based on the results of these .....
    Document: Peroxisome proliferator activated-receptors (PPARs), a group of ligand-activated nuclear transcription factors, may be involved in α-mannosidase expression during HBV infection. Indeed, tumor necrosis factor-α (TNF-α) has been shown to downregulate the expression of MAN1C1 to increase the expression of high-mannose type proteoglycans, and this can be reversed by the activation of the PPAR signaling pathway [14] . Based on the results of these previous studies, we hypothesized that HBV could promote the demannosylation of the viral protein by increasing the expression of α-mannosidase I in the host cells. In turn, DC-SIGN can no longer recognize the HBV glycoprotein coat, allowing the virus to escape from immune attack. In the present study, we investigated the effects of HBV infection on the expression of α-mannosidase I, and also determined the mechanisms driving the altered expression. We show for the first time that HBV infection increases the expression of α-mannosidase I via the PPARα signaling pathway.

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