Author: Hu, Song; Jiang, Li-Bin; Zou, Xiao-Jing; Yi, Wei; Tian, De-Ying
Title: Hepatitis B virus upregulates host expression of a-1,2-mannosidases via the PPARa pathway Document date: 2016_11_21
ID: w5m23ikh_30
Snippet: In conclusion, the findings of the present study showed that HBV could increase the expression of class â… Î±-mannosidases both in vitro and in vivo. Moreover, the HBV envelope protein increases the Figure 5 ). These findings suggest that the class â… Î±-mannosidases could be used as drug targets to inhibit the demannosylation of HBV, thereby improving the binding of the virus to DC-SIGN and disrupting the immune tolerance to prevent and treat .....
Document: In conclusion, the findings of the present study showed that HBV could increase the expression of class â… Î±-mannosidases both in vitro and in vivo. Moreover, the HBV envelope protein increases the Figure 5 ). These findings suggest that the class â… Î±-mannosidases could be used as drug targets to inhibit the demannosylation of HBV, thereby improving the binding of the virus to DC-SIGN and disrupting the immune tolerance to prevent and treat viral infection.
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