Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality

Seo, Sachiko; Waghmare, Alpana; Scott, Emily M; Xie, Hu; Kuypers, Jane M; Hackman, Robert C.; Campbell, Angela P.; Choi, Su-Mi; Leisenring, Wendy M.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael

This retrospective study includes patients who were transplanted between 1993 and 2015 at the Fred Hutchinson Cancer Research Center (FHCRC) and had virologically-confirmed HRV infection following HCT at the University of Washington Virology Laboratories. 13 Only an individual's first episode of HRV infection was analyzed. HRV upper respiratory tract infection (URI) was defined as HRV detection in a nasopharyngeal sample, and LRI was defined as HRV detection in a BAL or lung biopsy sample. Patients' demographic data and transplant information closest to the HRV infection were retrieved from the FHCRC database, and other data related to the clinical course of HRV infections were col-lected by medical chart review. As comparative cohorts, patients with LRI caused by respiratory syncytial virus (RSV), parainfluenza virus (PIV), or influenza virus were included in the analyses. [14] [15] [16] The first episode of LRI by any of the 4 viruses was selected and the cases with overlapped infections of the 4 viruses were excluded from the analyses. The study was approved by the Institutional Review Board at FHCRC.