Author: Zeng, Zhengyang; Zhang, Runhong; Hong, Wei; Cheng, Yuting; Wang, Huijuan; Lang, Yange; Ji, Zhenglin; Wu, Yingliang; Li, Wenxin; Xie, Youli; Cao, Zhijian
Title: Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1 Document date: 2018_1_1
ID: zilqyfjl_72
Snippet: HSV-1: Herpes simplex virus type 1; AMPs: antimicrobial peptides; CD spectroscopy: circular dichroism spectroscopy; PNS: peripheral nervous system; MAPK pathway: mitogen-activated protein kinase pathway; HNF4α: hepatocyte nuclear factor 4α; TFA: trifluoroacetic acid; HPLC: high performance liquid chromatography; MEM: minimum essential medium; FBS: fetal bovine serum; CPE: cytopathic effect; PBS: phosphate buffered saline; DMSO: dimethyl sulfoxi.....
Document: HSV-1: Herpes simplex virus type 1; AMPs: antimicrobial peptides; CD spectroscopy: circular dichroism spectroscopy; PNS: peripheral nervous system; MAPK pathway: mitogen-activated protein kinase pathway; HNF4α: hepatocyte nuclear factor 4α; TFA: trifluoroacetic acid; HPLC: high performance liquid chromatography; MEM: minimum essential medium; FBS: fetal bovine serum; CPE: cytopathic effect; PBS: phosphate buffered saline; DMSO: dimethyl sulfoxide; HEPES: 4-(2-hydroxyethyl)-1piperazineethanesulfonic acid; PFU: plaque-forming units; PRA: plaque reduction assay; MOI: multiplicity of infection; DAPI: 4',6-diamidino-2-phenylindole; FITC: fluorescein isothiocyanate; CC50: 50% cytotoxicity concentration; IC 50 : 50% inhibition concentration; SI: selecting index.
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