Author: He, Cheng; Kong, Ling; Zhou, Lijuan; Xia, Jing; Wei, Haixia; Liu, Min; Peng, Hongjuan
Title: Host Cell Vimentin Restrains Toxoplasma gondii Invasion and Phosphorylation of Vimentin is Partially Regulated by Interaction with TgROP18 Document date: 2017_9_5
ID: z9mg639h_26
Snippet: Together, the findings of this study indicated that host cell vimentin rearrangement around PVs occurred during T. gondii infection, and that phosphorylation and solubility of vimentin were regulated by T. gondii infection, but only partially by TgROP18, which may be associated with vimentin reorganization to facilitate T. gondii invasion. Moreover, expression levels of vimentin were affected by T. gondii infection, but not by TgROP18. Furthermor.....
Document: Together, the findings of this study indicated that host cell vimentin rearrangement around PVs occurred during T. gondii infection, and that phosphorylation and solubility of vimentin were regulated by T. gondii infection, but only partially by TgROP18, which may be associated with vimentin reorganization to facilitate T. gondii invasion. Moreover, expression levels of vimentin were affected by T. gondii infection, but not by TgROP18. Furthermore host cell vimentin was phosphorylated by TgROP18 and played an important role in the inhibition of T. gondii invasion. Our findings revealed a new mechanism of T. gondii regulation on host cell cytoskeleton reorganization through its effects on vimentin phosphorylation, solubility, and expression, and the contribution of TgROP18 to this regulatory process.
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