Selected article for: "high dose and immune response"
Author: Cao, Wei; Liu, Xiaosheng; Bai, Tao; Fan, Hongwei; Hong, Ke; Song, Hui; Han, Yang; Lin, Ling; Ruan, Lianguo; Li, Taisheng
Title: High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019
  • Document date: 2020_3_21
    • ID: u3gmpklc_2
    Snippet: The clinical spectrum of SARS-CoV-2 infection is quite wide and includes asymptomatic infection and mild type, with only upper respiratory tract illness, common type with pulmonary infiltrations, severe type with respiratory distress, and critically ill patients needing intubation or intensive care [2] . Clinical features of those with pneumonia include fever and cough, and in many cases a sudden and accelerating respiratory distress originated f.....
    Document: The clinical spectrum of SARS-CoV-2 infection is quite wide and includes asymptomatic infection and mild type, with only upper respiratory tract illness, common type with pulmonary infiltrations, severe type with respiratory distress, and critically ill patients needing intubation or intensive care [2] . Clinical features of those with pneumonia include fever and cough, and in many cases a sudden and accelerating respiratory distress originated from interstitial pneumonia. In those who rapidly progressed to critical conditions, reduced peripheral lymphocyte counts and elevated inflammatory factors were observed, indicating an overwhelming immune response [3, 4] . Previous experiences with SARS showed that the main pathogenesis of organ dysfunction lay in the overall cytokine dysregulation. Similarly, the point when status deterioration starts in patients with COVID-19 should be a critical window of opportunity for intervention. Here we report on 3 patients with COVID-19 who received high-dose intravenous immunoglobulin (IVIg) at the time of initiation of respiratory distress, with satisfactory clinical and radiographic recovery.

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