Selected article for: "extrinsic factor and intrinsic factor"
Author: Bian, Qian; Lu, Jing; Zhang, Li; Chi, Ying; Li, Yan; Guo, Hongxiong
Title: Highly pathogenic avian influenza A virus H5N1 non-structural protein 1 is associated with apoptotic activation of the intrinsic mitochondrial pathway
  • Document date: 2017_8_28
    • ID: s6kpewt6_2
    Snippet: At present, two main apoptotic pathways have been documented; the tumor necrosis factor (TNF) receptor-mediated extrinsic pathway and the intrinsic pathway mediated by mitochondria/cytochrome c (7) . The non-structural protein 1 (NS1), which is encoded by the influenza virus NS segment, is able to alter the host response and virulence of the virus in the case of reassortment without prior adaptation (8, 9) , and is associated with apoptosis regul.....
    Document: At present, two main apoptotic pathways have been documented; the tumor necrosis factor (TNF) receptor-mediated extrinsic pathway and the intrinsic pathway mediated by mitochondria/cytochrome c (7) . The non-structural protein 1 (NS1), which is encoded by the influenza virus NS segment, is able to alter the host response and virulence of the virus in the case of reassortment without prior adaptation (8, 9) , and is associated with apoptosis regulation in mammalian cells. Previous studies revealed that the H5N1 NS1 protein induced the TNF-mediated extrinsic apoptosis pathway in human alveolar basal epithelial cells (10) (11) (12) (13) . However, the susceptible cell lines of the various pathogenic avian influenza viruses are different, which causes them to vary in their responses to apoptosis (14, 15) .

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