Author: Wang, Xue-Jiao; Zhang, Jun; Wang, Shu-Qing; Xu, Wei-Ren; Cheng, Xian-Chao; Wang, Run-Ling
Title: Identification of novel multitargeted PPARa/?/d pan agonists by core hopping of rosiglitazone Document date: 2014_11_7
ID: uotug8ej_4
Snippet: Wang et al tail of PPARs agonists could bind to the residues at the active site entrance, affecting subtype selectivity. This indicates that by modification of the polar head and hydrophobic tail, various pharmacological effects can be produced, such as PPARα/γ dual agonistic activity and PPARα/γ/δ pan agonistic activity......
Document: Wang et al tail of PPARs agonists could bind to the residues at the active site entrance, affecting subtype selectivity. This indicates that by modification of the polar head and hydrophobic tail, various pharmacological effects can be produced, such as PPARα/γ dual agonistic activity and PPARα/γ/δ pan agonistic activity.
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