Selected article for: "immune signaling and innate immune signaling"
Author: Girardi, Erika; Chane-Woon-Ming, Béatrice; Messmer, Mélanie; Kaukinen, Pasi; Pfeffer, Sébastien
Title: Identification of RNase L-Dependent, 3'-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells
  • Document date: 2013_11_19
    • ID: v6uc0ijw_38
    Snippet: The main protective mechanism against 3=-5= degradation is a 2=-O-methylation on the 3= proximal ribose, which prevents degradation by exoribonucleases and thus helps to stabilize small RNAs such as miRNAs and siRNAs in plants, piRNAs in animals, and siRNAs in Drosophila melanogaster (52) . This suggests that RNA modification could have evolved as a response to protect the anti-pathogen small RNAs during infections. Posttranscriptional RNA modifi.....
    Document: The main protective mechanism against 3=-5= degradation is a 2=-O-methylation on the 3= proximal ribose, which prevents degradation by exoribonucleases and thus helps to stabilize small RNAs such as miRNAs and siRNAs in plants, piRNAs in animals, and siRNAs in Drosophila melanogaster (52) . This suggests that RNA modification could have evolved as a response to protect the anti-pathogen small RNAs during infections. Posttranscriptional RNA modifications represent an important but not yet fully understood system to regulate transcripts. Cellular RNAs contain many distinct posttranscriptional modifications at thousands of sites. In the same way, RNA viruses take advantage of nucleoside modifications on the base or on the ribose of their genomic RNA (36, 53) as a host mimicry strategy to abrogate innate immune signaling (54) .

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