Author: Seo, Sachiko; Waghmare, Alpana; Scott, Emily M; Xie, Hu; Kuypers, Jane M; Hackman, Robert C.; Campbell, Angela P.; Choi, Su-Mi; Leisenring, Wendy M.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael
Title: Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality Document date: 2017_6_23
ID: t7qk6evo_32
Snippet: In conclusion, we provide further evidence that HRV is a serious pathogen in the lower respiratory tract of HCT recipients. This conclusion is supported by similar outcomes of patients with HRV in the BAL compared to those with well-established respiratory pathogens such as RSV and influenza virus and by the presence of HRV in lung tissue. The data are also consistent with the recent literature on HRV in other clinical settings, which supports a .....
Document: In conclusion, we provide further evidence that HRV is a serious pathogen in the lower respiratory tract of HCT recipients. This conclusion is supported by similar outcomes of patients with HRV in the BAL compared to those with well-established respiratory pathogens such as RSV and influenza virus and by the presence of HRV in lung tissue. The data are also consistent with the recent literature on HRV in other clinical settings, which supports a potential causal role in serious clinical disease, 1 and agree with earlier studies in HCT recipients carried out prior to the use of molecular diagnostic techniques. 6, 7 However, while these data are supportive of a pathogenic role of HRV, ultimate proof could best be provided by randomized placebo-controlled trials. These data provide the rationale for the rapid development and clinical evaluation of new therapeutics.
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