Author: Ranjbar, Shahin; Haridas, Viraga; Jasenosky, Luke D.; Falvo, James V.; Goldfeld, Anne E.
Title: A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection Document date: 2015_10_22
ID: zy82bo7q_6
Snippet: To determine whether MTb infection induces transcriptional activation of the IFITMs, we infected primary human monocyte-derived macrophages (MDMs) with the clinical MTb strains CDC1551 and HN878 and measured IFITM1-3 mRNA levels at 3, 24, and 48 hr post-infection. All three genes were significantly induced by CDC1551 and HN878 ( Figure 1A) in MDMs, and a similar response was seen at 6, 24, and 48 hr in H37Rv-MTb-infected THP-1 monocytes ( Figure.....
Document: To determine whether MTb infection induces transcriptional activation of the IFITMs, we infected primary human monocyte-derived macrophages (MDMs) with the clinical MTb strains CDC1551 and HN878 and measured IFITM1-3 mRNA levels at 3, 24, and 48 hr post-infection. All three genes were significantly induced by CDC1551 and HN878 ( Figure 1A) in MDMs, and a similar response was seen at 6, 24, and 48 hr in H37Rv-MTb-infected THP-1 monocytes ( Figure 1B ).
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