Author: Girardi, Erika; Chane-Woon-Ming, Béatrice; Messmer, Mélanie; Kaukinen, Pasi; Pfeffer, Sébastien
Title: Identification of RNase L-Dependent, 3'-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells Document date: 2013_11_19
ID: v6uc0ijw_2
Snippet: In mammals, another type of innate immunity has evolved to control viruses (2) . The initial recognition of nonself viral nucleic acids by extra-and intracellular sensors triggers the activation of type I interferons (IFNs) (3) . This leads in turn to the upregulation of numerous IFN-stimulated genes (ISGs) (4) , which either directly trigger a signaling cascade directed against the viral infection or mobilize other cells of the immune system. IS.....
Document: In mammals, another type of innate immunity has evolved to control viruses (2) . The initial recognition of nonself viral nucleic acids by extra-and intracellular sensors triggers the activation of type I interferons (IFNs) (3) . This leads in turn to the upregulation of numerous IFN-stimulated genes (ISGs) (4) , which either directly trigger a signaling cascade directed against the viral infection or mobilize other cells of the immune system. ISGs encode proteins involved in apoptosis induction, protein synthesis blocking, or in the regulation of mRNA editing or RNA degradation (5) .
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