Selected article for: "cell anergy and enzyme catalytic activity"
Author: Lippens, Carla; Duraes, Fernanda V.; Dubrot, Juan; Brighouse, Dale; Lacroix, Mathilde; Irla, Magali; Aubry-Lachainaye, Jean-Pierre; Reith, Walter; Mandl, Judith N.; Hugues, Stéphanie
Title: IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
  • Document date: 2016_12_23
    • ID: sl8148ap_4
    Snippet: CTLA-4-binding also promote IDO in tumor contexts, but the enzyme has reveal activity in only a minor DC subpopulation expressing the marker CD19, but none of the pDC classical markers [32], [33]. IDO enzymatic functions in tumor dLN-sorted pDCs have been correlated to in vitro Treg differentiation and suppressive functions [24], [34]. More recently, Pallotta and colleagues described that IDO+ pDCs induced long-lived Tregs by using a TGF-β-depen.....
    Document: CTLA-4-binding also promote IDO in tumor contexts, but the enzyme has reveal activity in only a minor DC subpopulation expressing the marker CD19, but none of the pDC classical markers [32], [33]. IDO enzymatic functions in tumor dLN-sorted pDCs have been correlated to in vitro Treg differentiation and suppressive functions [24], [34]. More recently, Pallotta and colleagues described that IDO+ pDCs induced long-lived Tregs by using a TGF-β-dependent pathway distinct from the catalytic activity of the enzyme. In mouse a model of skin delayed-type hypersensitivity, they shown that whereas IFN-γ-dependent IDO enzymatic activity in pDCs leads to T cell anergy, TGF-β induced IDO phosphorylation results in increased Treg frequencies [35].

    Search related documents:
    Co phrase search for related documents
    • catalytic activity and enzymatic activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • catalytic activity and enzymatic function: 1, 2
    • catalytic activity and enzyme catalytic activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • catalytic activity and IDO promote: 1
    • catalytic activity and phosphorylation result: 1
    • cell anergy and enzyme catalytic activity: 1
    • cell anergy and IDO promote: 1
    • enzymatic activity and phosphorylation result: 1
    • enzyme catalytic activity and IDO promote: 1