Selected article for: "IDO expression and steady state"
Author: Lippens, Carla; Duraes, Fernanda V.; Dubrot, Juan; Brighouse, Dale; Lacroix, Mathilde; Irla, Magali; Aubry-Lachainaye, Jean-Pierre; Reith, Walter; Mandl, Judith N.; Hugues, Stéphanie
Title: IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
  • Document date: 2016_12_23
    • ID: sl8148ap_5
    Snippet: It is so far unknown whether IDO expression in naïve pDCs pre-exists, and how it would be regulated in steady-state LNs. In contrast, recent work has implicated IDO expression in pDC immunoregulatory functions, including Treg induction, in inflamed LNs. Furthermore, IDO production by tumor-associated pDCs has been correlated to in vitro Treg-mediated suppression. However, the nature of the cells expressing IDO, as well as the impact on Treg func.....
    Document: It is so far unknown whether IDO expression in naïve pDCs pre-exists, and how it would be regulated in steady-state LNs. In contrast, recent work has implicated IDO expression in pDC immunoregulatory functions, including Treg induction, in inflamed LNs. Furthermore, IDO production by tumor-associated pDCs has been correlated to in vitro Treg-mediated suppression. However, the nature of the cells expressing IDO, as well as the impact on Treg functions in chronic inflammatory diseases, such as autoimmune disorders, remain undetermined.

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