Selected article for: "energy transfer and fluorescence resonance"
Author: Jo, Seri; Kim, Suwon; Shin, Dong Hae; Kim, Mi-Sun
Title: Inhibition of SARS-CoV 3CL protease by flavonoids
  • Document date: 2019_11_14
    • ID: vynk8q8c_3
    Snippet: In this study, we employed a proteolytic method to probe SARS-CoV 3CLpro inhibitory compounds. A synthetic peptide labelled with an Edans-Dabcyl FRET (Fluorescence resonance energy transfer) pair 12 was used to search SARS-CoV 3CLpro inhibitory compounds against a flavonoid library. Recent studies showed that flavonoids have antiviral activity in some viruses including SARS-CoV 13-17 . However, a molecular level study has not been reported for SA.....
    Document: In this study, we employed a proteolytic method to probe SARS-CoV 3CLpro inhibitory compounds. A synthetic peptide labelled with an Edans-Dabcyl FRET (Fluorescence resonance energy transfer) pair 12 was used to search SARS-CoV 3CLpro inhibitory compounds against a flavonoid library. Recent studies showed that flavonoids have antiviral activity in some viruses including SARS-CoV 13-17 . However, a molecular level study has not been reported for SARS-CoV. Therefore, we performed the proteolytic assay with flavonoids followed by an induced-fit docking experiment with top hits. With the results, we tried to deduce a structural and functional relationship of flavonoids crucial to binding with SARS-CoV 3CLpro. The information can be applied to develop synthetic compounds with better affinities.

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