Selected article for: "mrna level and protein level"
Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress
  • Document date: 2017_2_28
    • ID: w731ehtz_7
    Snippet: ISG15 is also induced by genotoxic stresses. UV was first shown to increase the level of ISG15 transcripts by about four fold in human skin fibroblasts (Gentile et al., 2003) . Camptothecin, an inhibitor of topoisomerase I, also increases the level of ISG15 mRNA and this increase requires protein synthesis and a functional p53 protein (Liu et al., 2004) . Significantly, camptothecin-mediated induction of ISG15 is independent of IFN signaling path.....
    Document: ISG15 is also induced by genotoxic stresses. UV was first shown to increase the level of ISG15 transcripts by about four fold in human skin fibroblasts (Gentile et al., 2003) . Camptothecin, an inhibitor of topoisomerase I, also increases the level of ISG15 mRNA and this increase requires protein synthesis and a functional p53 protein (Liu et al., 2004) . Significantly, camptothecin-mediated induction of ISG15 is independent of IFN signaling pathway and ISG15 conjugates formed by the drug treatment are different from those generated by type I IFNs, indicating that different signals induce ISGylation of different target proteins (Park et al., 2016) .

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