Author: Linder, Kathleen A; McDonald, Philip J; Kauffman, Carol A; Revankar, Sanjay G; Chandrasekar, Pranatharthi H; Miceli, Marisa H
Title: Infectious Complications After Umbilical Cord Blood Transplantation for Hematological Malignancy Document date: 2019_2_22
ID: qu20hqch_40
Snippet: Not surprisingly, bacterial infections were common throughout all time periods, and many were likely related to the presence of indwelling catheters. Infections with Enterobacteriaceae and VRE within the first 30 days after UCBT were associated with increased mortality. The prolonged time to neutrophil engraftment after UCBT increases the period at which recipients are at high risk of life-threatening bacterial infections. Although antibacterial .....
Document: Not surprisingly, bacterial infections were common throughout all time periods, and many were likely related to the presence of indwelling catheters. Infections with Enterobacteriaceae and VRE within the first 30 days after UCBT were associated with increased mortality. The prolonged time to neutrophil engraftment after UCBT increases the period at which recipients are at high risk of life-threatening bacterial infections. Although antibacterial prophylaxis is standard of care after HCT, increasing antimicrobial resistance limits the efficacy of several existing oral prophylactic regimens [30] . In some centers, VRE has become the most common cause of bacteremia in allogeneic HCT recipients and also has emerged as a problem among UCBT recipients in some centers [13, [30] [31] [32] [33] [34] .
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