Selected article for: "laboratory testing and RNA detection"
Author: Huh, Hee Jae; Ko, Jae-Hoon; Kim, Young-Eun; Park, Chang-Hun; Hong, Geehay; Choi, Rihwa; Yu, Shinae; Cho, Sun Young; Kang, Ji-Man; Lee, Myoung-Keun; Ki, Chang-Seok; Kang, Eun-Suk; Lee, Nam Yong; Kim, Jong-Won; Kim, Yae-Jean; Ha, Young Eun; Kang, Cheol-In; Chung, Doo Ryeon; Peck, Kyong Ran; Song, Jae-Hoon
Title: Importance of Specimen Type and Quality in Diagnosing Middle East Respiratory Syndrome
  • Document date: 2016_11_1
    • ID: s958dq2q_4
    Snippet: In the study period, 42 inconclusive results were obtained, including 17 equivocal results and 25 indeterminate results. In many of the confirmed MERS patients (16/51, 31.4%), the initial tests were negative or inconclusive, with not only URT but also LRT specimens. Fig. 1 shows a schematic plot of the detection for MERS-CoV RNA in respiratory tract specimens for the 16 laboratory-confirmed cases. Of note, four consecutive tests yielded negative .....
    Document: In the study period, 42 inconclusive results were obtained, including 17 equivocal results and 25 indeterminate results. In many of the confirmed MERS patients (16/51, 31.4%), the initial tests were negative or inconclusive, with not only URT but also LRT specimens. Fig. 1 shows a schematic plot of the detection for MERS-CoV RNA in respiratory tract specimens for the 16 laboratory-confirmed cases. Of note, four consecutive tests yielded negative results in one confirmed case. The patient was confirmed to be MERS-positive on the fifth test. These findings highlight the importance of implementing guidelines for laboratory testing, where patients should be retested by using a LRT specimen if initial testing is inconclusive or negative in a patient who is suspected to have MERS-CoV infection [1, 2] .

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