Selected article for: "cytokine storm and severity correlate"

Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection
  • Document date: 2011_6_15
  • ID: qos9vu3r_2
    Snippet: DHF is more common in individuals undergoing secondary heterologous dengue infection than those suffering primary infections. There has been considerable work to understand the mechanism of severe disease, but the increased frequency during secondary infection and the occurrence of severe symptoms at a time when virus loads are falling sharply imply that it likely results from immunopathology driven by the acquired immune responses, rather than f.....
    Document: DHF is more common in individuals undergoing secondary heterologous dengue infection than those suffering primary infections. There has been considerable work to understand the mechanism of severe disease, but the increased frequency during secondary infection and the occurrence of severe symptoms at a time when virus loads are falling sharply imply that it likely results from immunopathology driven by the acquired immune responses, rather than from direct viral cytopathology [1] [2] [3] [4] . Levels of a number of cytokines, such as interferon c and tumor necrosis factor a [5, 6] , have been shown to correlate with disease severity, and a storm of inflammatory cytokine secretion has been proposed to lead to the vascular leak characteristic of DHF.

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