Selected article for: "liver tissue and lung endothelial"
Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection
  • Document date: 2011_6_15
    • ID: qos9vu3r_42
    Snippet: In humans, L-SIGN expression is restricted to endothelial cells beneath the subcapsular sinus in lymph nodes [40] , sinusoidal endothelial cells in the liver [27, 41] , alveolar and endothelial cells in the lung [42] , and capillaries in the villous lamina propria of terminal ileum and Peyer patches [43] . Dengue antigens have been demonstrated in the sinusoidal tissue of the liver and vascular endothelium of the lung and spleen and may provide a.....
    Document: In humans, L-SIGN expression is restricted to endothelial cells beneath the subcapsular sinus in lymph nodes [40] , sinusoidal endothelial cells in the liver [27, 41] , alveolar and endothelial cells in the lung [42] , and capillaries in the villous lamina propria of terminal ileum and Peyer patches [43] . Dengue antigens have been demonstrated in the sinusoidal tissue of the liver and vascular endothelium of the lung and spleen and may provide an explanation for the unique pathology observed in these organs [44, 45] . The accumulation of antigen in L-SIGNexpressing tissue may also result in an increase in localized transinfection in a similar way that L-SIGN is thought to be responsible for the capture of HCV from the blood and transmission to hepatocytes or in the case of HIV, to CD4 1 T cells [28, 41] .

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