Author: Girardi, Erika; Chane-Woon-Ming, Béatrice; Messmer, Mélanie; Kaukinen, Pasi; Pfeffer, Sébastien
Title: Identification of RNase L-Dependent, 3'-End-Modified, Viral Small RNAs in Sindbis Virus-Infected Mammalian Cells Document date: 2013_11_19
ID: v6uc0ijw_31
Snippet: The size distribution of the viral reads remained unchanged before and after NaIO 4 treatment, indicating that SINV-derived modified RNAs belonged to each length (Fig. 5B) . Finally, we analyzed the nucleotide composition of the 3= end of SINV small RNAs and observed that we had enrichment in adenosine (A) at the 3= end after oxidation, which was not clearly discernible in the nontreated sample (Fig. 5C ). This is in line with the specific 2=-Ome.....
Document: The size distribution of the viral reads remained unchanged before and after NaIO 4 treatment, indicating that SINV-derived modified RNAs belonged to each length (Fig. 5B) . Finally, we analyzed the nucleotide composition of the 3= end of SINV small RNAs and observed that we had enrichment in adenosine (A) at the 3= end after oxidation, which was not clearly discernible in the nontreated sample (Fig. 5C ). This is in line with the specific 2=-Omethylation occurring on internal adenosines recently identified on the genome of dengue virus (36) .
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