Author: Stenglein, Mark D.; Sanders, Chris; Kistler, Amy L.; Ruby, J. Graham; Franco, Jessica Y.; Reavill, Drury R.; Dunker, Freeland; DeRisi, Joseph L.
Title: Identification, Characterization, and In Vitro Culture of Highly Divergent Arenaviruses from Boa Constrictors and Annulated Tree Boas: Candidate Etiological Agents for Snake Inclusion Body Disease Document date: 2012_8_14
ID: vkhg20he_15
Snippet: Previously described arenaviruses encode a small RING domain-containing zinc binding protein (Z) on the L segment and a glycoprotein precursor (GPC) on the S segment (20, 21, 27, 28) . There are ORFs encoding proteins with similar predicted functional domains at the same genomic positions of the snake viruses, but their evolutionary relationship to the arenavirus Z and GPC genes is less clear. The predicted protein sequences did not possess detec.....
Document: Previously described arenaviruses encode a small RING domain-containing zinc binding protein (Z) on the L segment and a glycoprotein precursor (GPC) on the S segment (20, 21, 27, 28) . There are ORFs encoding proteins with similar predicted functional domains at the same genomic positions of the snake viruses, but their evolutionary relationship to the arenavirus Z and GPC genes is less clear. The predicted protein sequences did not possess detectable direct homology with previously described arenavirus Z and GPC sequences, as measured by BLASTP against the nr database using an expect value cutoff of 0.1. Instead, they were more similar to other viral and nonviral proteins.
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