Title: Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence Document date: 1993_3_1
ID: qt44izzh_23
Snippet: To determine whether defined regions of the TGN38 molecule contained information that was sufficient for TGN localization, chimeric proteins were constructed by exchanging domains between TGN38 and the Tac antigen (interleukin-2 receptor c~ chain, Leonard et al., 1984) (Fig. 1, top) . The Tac antigen is a type I integral membrane protein with a topological organization similar to that of TGN38 ( Fig. 1, top). Unlike TGN38, however, Tac is primari.....
Document: To determine whether defined regions of the TGN38 molecule contained information that was sufficient for TGN localization, chimeric proteins were constructed by exchanging domains between TGN38 and the Tac antigen (interleukin-2 receptor c~ chain, Leonard et al., 1984) (Fig. 1, top) . The Tac antigen is a type I integral membrane protein with a topological organization similar to that of TGN38 ( Fig. 1, top). Unlike TGN38, however, Tac is primarily localized to the cell surface (Leonard et al., 1984; Weissman et al., 1986; Bonifacino et al., 1990) .
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