Author: Cho, Sung-Yeon; Lee, Hyeon-Jeong; Lee, Dong-Gun
Title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea Document date: 2018_2_27
ID: t9tysvr8_33
Snippet: The major symptoms of Pneumocystis jirovecii pneumonia (PCP) are fever, difficulty breathing, and dry cough rather than purulent sputum. Typical radiologic findings are bilateral diffuse infiltrates originating from the periphery of both lungs, but may be normal at the beginning. PCP can present as segmental consolidation in the upper lobe, or subtle ground glass opacities and pneumothorax. It usually occurs within 6 months after transplantation .....
Document: The major symptoms of Pneumocystis jirovecii pneumonia (PCP) are fever, difficulty breathing, and dry cough rather than purulent sputum. Typical radiologic findings are bilateral diffuse infiltrates originating from the periphery of both lungs, but may be normal at the beginning. PCP can present as segmental consolidation in the upper lobe, or subtle ground glass opacities and pneumothorax. It usually occurs within 6 months after transplantation but also after 6 months of immunosup-pressive therapy for chronic GVHD [3, 4] . The known risk factors for PCP in hematologic patients are acute lymphoblastic leukemia, allogeneic HSCT recipients, alemtuzumab, fludarabine, cyclophosphamide, rituximab, and steroid use (> 20 mg/day prednisone for 4 weeks) [64] .
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