Author: Liu, Yan-Cun; Zou, Xian-Biao; Chai, Yan-Fen; Yao, Yong-Ming
Title: Macrophage Polarization in Inflammatory Diseases Document date: 2014_5_1
ID: u1io62e3_16
Snippet: Both pro-atherosclerotic and anti-atherosclerotic functions have been demonstrated for M2 macrophages in atherosclerosis. IL-4 dependent macrophages expressed CD36, and they promoted oxidized low-density lipoprotein uptake and were abnormally high in patients with symptomatic atherosclerotic carotid plaques [49] . 15-lipoxygenase expressed by M2 macrophages linked to formation of foam cell and was critical for the development of atherosclerotic p.....
Document: Both pro-atherosclerotic and anti-atherosclerotic functions have been demonstrated for M2 macrophages in atherosclerosis. IL-4 dependent macrophages expressed CD36, and they promoted oxidized low-density lipoprotein uptake and were abnormally high in patients with symptomatic atherosclerotic carotid plaques [49] . 15-lipoxygenase expressed by M2 macrophages linked to formation of foam cell and was critical for the development of atherosclerotic plaques [50] . TGF-β, secreted by M2 phenotype macrophages, inhibited the recruitment of inflammatory cells and was associated with a significant protection against atherosclerosis [51] . Efferocytosis, engulfing the apoptotic macrophages to prevent the formation of secondary necrosis, was defective in advanced atherosclerotic plaque and contributed to the formation of a vulnerable plaque [52] .
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