Selected article for: "mitochondrial dna and mouse model"
Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA
  • Document date: 2018_6_28
    • ID: tudwns0r_27
    Snippet: In summary, FMCA and its phosphoramidate prodrug, FMCA-P, were fully active against HBV strains resistant to lamivudine, entecavir, adefovir and tenofovir. FMCA appears to have a good safety profile, having minimal inhibitory effects on cellular and mitochondrial DNA replication. Compared to entecavir, the good safety profile enables higher doses of FMCA-P to be used in efficacy studies using a mouse model. Further in vivo evaluation of FMCA-P is.....
    Document: In summary, FMCA and its phosphoramidate prodrug, FMCA-P, were fully active against HBV strains resistant to lamivudine, entecavir, adefovir and tenofovir. FMCA appears to have a good safety profile, having minimal inhibitory effects on cellular and mitochondrial DNA replication. Compared to entecavir, the good safety profile enables higher doses of FMCA-P to be used in efficacy studies using a mouse model. Further in vivo evaluation of FMCA-P is ongoing. Although pre-existing HBV cccDNA is not eliminated by therapy with nucleoside/tide analogues, such drugs will play a vital role in controlling HBV replication while minimising drug resistance.

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