Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA Document date: 2018_6_28
ID: tudwns0r_72
Snippet: To investigate this idea experimentally, at a median of 45 days after the estimated date of infection, the viral burden, levels of inflammatory cytokines, cellular immune activation and exhaustion and depletion of different CD4þ memory T cells were measured. It was shown that high vRC virus is linked to enhanced levels of inflammatory cytokines, driving T cell dysfunction and increased viral burden in naı¨ve CD4þ T cells and CD4þ memory T ce.....
Document: To investigate this idea experimentally, at a median of 45 days after the estimated date of infection, the viral burden, levels of inflammatory cytokines, cellular immune activation and exhaustion and depletion of different CD4þ memory T cells were measured. It was shown that high vRC virus is linked to enhanced levels of inflammatory cytokines, driving T cell dysfunction and increased viral burden in naı¨ve CD4þ T cells and CD4þ memory T cells. This finding is linked to significantly faster decline of CD4 cells. Therefore, what happens early in an infection can only be modulated by the adaptive immune system, reversal is not possible.
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