Selected article for: "endothelial dysfunction and important role"
Author: Shim, Yoon Hee; Kim, Hae Soon; Sohn, Sejung; Hong, Young Mi
Title: Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene in Kawasaki Disease
  • Document date: 2006_4_20
    • ID: wup6tig0_3
    Snippet: Angiotensin converting enzyme (ACE) breaks down the potent vasodilator, bradykinin to its inactivate metabolite and catalyzes angiotensin I to angiotensin II. Angiotensin II promotes hyperplasia and hypertrophy of vascular smooth muscle cells, induces the production of proinflammatory cytokines and causes endothelial dysfunction by free radical generation. By playing an important role in cardiovascular regulatory system, ACE gene has been propose.....
    Document: Angiotensin converting enzyme (ACE) breaks down the potent vasodilator, bradykinin to its inactivate metabolite and catalyzes angiotensin I to angiotensin II. Angiotensin II promotes hyperplasia and hypertrophy of vascular smooth muscle cells, induces the production of proinflammatory cytokines and causes endothelial dysfunction by free radical generation. By playing an important role in cardiovascular regulatory system, ACE gene has been proposed to be associated with various cardiovascular diseases, such as ischemic heart disease, hypertrophic cardiomyopathy, idiopathic dilated cardiomyopathy, and vascular hypertrophy (14) . Among the different ACE genetic loci, the insertion/deletion polymorphism coded within intron 16 has been studied in many literature to find the association with such diseases.

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