Author: Morgan, Brittany S; Forte, Jordan E; Hargrove, Amanda E
Title: Insights into the development of chemical probes for RNA Document date: 2018_9_19
ID: wupre5uj_44
Snippet: For comparison, we note that over a decade ago chemical probe discovery for another 'undruggable' target, protein:protein interactions, was in its infancy with only 19 known small molecule inhibitors (108) . However, novel advances in screening approaches and design strategies led to the rapid discovery of thousands of protein:protein interaction inhibitors with several entering the clinic and most also breaking the rules of 'drug-like chemical s.....
Document: For comparison, we note that over a decade ago chemical probe discovery for another 'undruggable' target, protein:protein interactions, was in its infancy with only 19 known small molecule inhibitors (108) . However, novel advances in screening approaches and design strategies led to the rapid discovery of thousands of protein:protein interaction inhibitors with several entering the clinic and most also breaking the rules of 'drug-like chemical space' (109) . In the next five years, we anticipate that the innovations described herein and the ones yet to be discovered will lead to a similar surge in reports of RNA-based chemical probes and therapeutics. We also expect that novel and well-characterized chemical probes will allow RNA biologists to uncover many more exciting and unanticipated roles for RNA, propelling us into the next phase of the RNA revolution.
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