Author: Uzoma, Ijeoma; Zhu, Heng
Title: Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks Document date: 2013_1_17
ID: t96j8qt0_19
Snippet: Protein microarrays allow for exploration of hypotheses that cannot be addressed by standard methods. Investigating the interactions between viral encoded proteins and the proteins within the infected host has been an important yet cumbersome task. Protein microarrays composed of either the host or the viral proteome can be fabricated and subsequently used to examine the relationships between the viral machinery and the host. This in vitro approa.....
Document: Protein microarrays allow for exploration of hypotheses that cannot be addressed by standard methods. Investigating the interactions between viral encoded proteins and the proteins within the infected host has been an important yet cumbersome task. Protein microarrays composed of either the host or the viral proteome can be fabricated and subsequently used to examine the relationships between the viral machinery and the host. This in vitro approach recapitulates viral infection in that the viral genome/proteome are allowed to physically interact with the host. The Hayward and Zhu groups have recently developed this new paradigm to examine direct interactions between viral and host proteins [14, 35, 36] , leading to a deeper understanding of the mechanisms by which the viral proteins hijack the host as well as uncovering the direct targets of major viral enzymes.
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