Author: Jeon, Young Joo; Park, Jong Ho; Chung, Chin Ha
Title: Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress Document date: 2017_2_28
ID: w731ehtz_21
Snippet: Furthermore, ISGylation of ï„Np63ï¡ abrogates its ability to induce cell growth and tumor formation (Jeon et al., 2012) . Knockdown of ISG15, Lys-to-Arg mutations of ISGylation sites, or Asp-to-Ala mutations of cleavage sites by caspase-2 strongly potentiate the ability of ï„Np63ï¡ to promote anchorage-independent cell growth and tumor development in vivo. These findings indicate that ISG15 and its conjugation to ï„Np63ï¡ play critical role.....
Document: Furthermore, ISGylation of ï„Np63ï¡ abrogates its ability to induce cell growth and tumor formation (Jeon et al., 2012) . Knockdown of ISG15, Lys-to-Arg mutations of ISGylation sites, or Asp-to-Ala mutations of cleavage sites by caspase-2 strongly potentiate the ability of ï„Np63ï¡ to promote anchorage-independent cell growth and tumor development in vivo. These findings indicate that ISG15 and its conjugation to ï„Np63ï¡ play critical roles in suppression of tumorigenesis particularly in epithelial cancer cells under genotoxic stress conditions. As both camptothecin and doxorubicin are well-known anticancer drugs, these findings also provide a molecular basis for chemotherapeutic drugs against ï„Np63ï¡mediated cancers.
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