Author: Xue, Wenhua; Yan, Dan; Kan, Quancheng
Title: Interleukin-35 as an Emerging Player in Tumor Microenvironment Document date: 2019_5_12
ID: zxrgkhmr_3
Snippet: Although IL-35 is mostly expressed in Treg cells but recent evidences have uncovered its much larger tissue distribution [11] . Various reports have indicated the presence of EBI3 and IL-12 p35, subunits of IL-35, in placental trophoblasts [19] , Hodgkin lymphoma cells [10] , acute myeloid leukemia cells [20] , lung cancer cells [21] esophageal carcinoma, hepatocellular carcinoma, cervical carcinoma, and colorectal cancer [22, 23] . Similar studi.....
Document: Although IL-35 is mostly expressed in Treg cells but recent evidences have uncovered its much larger tissue distribution [11] . Various reports have indicated the presence of EBI3 and IL-12 p35, subunits of IL-35, in placental trophoblasts [19] , Hodgkin lymphoma cells [10] , acute myeloid leukemia cells [20] , lung cancer cells [21] esophageal carcinoma, hepatocellular carcinoma, cervical carcinoma, and colorectal cancer [22, 23] . Similar studies have pointed Ivyspring International Publisher IL-35 as a major player in tumor microenvironment (TME) [24] . The presence of Foxp3 + Treg cells and Treg cells in TME is demonstrated as one of the sources of IL-35 production [25, 26] .
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