Author: Glennie, S; Gritzfeld, J F; Pennington, S H; Garner-Jones, M; Coombes, N; Hopkins, M J; Vadesilho, C F; Miyaji, E N; Wang, D; Wright, A D; Collins, A M; Gordon, S B; Ferreira, D M
Title: Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage Document date: 2015_4_29
ID: st475jw7_14
Snippet: We then investigated whether purified anti-PspC IgG could block pneumococcal adherence and internalization to host epithelial cells. Epithelial adherence was reduced by purified anti-PspC IgG (Figure 4c , gray dots) containing 3.5 mg ml À 1 of residual FH (residual from anti-PspC purification process, Supplementary Figure S1C ) but not in the presence of higher levels of FH (20 mg ml À 1 ; Figure 4c , open dots). This interaction was specific t.....
Document: We then investigated whether purified anti-PspC IgG could block pneumococcal adherence and internalization to host epithelial cells. Epithelial adherence was reduced by purified anti-PspC IgG (Figure 4c , gray dots) containing 3.5 mg ml À 1 of residual FH (residual from anti-PspC purification process, Supplementary Figure S1C ) but not in the presence of higher levels of FH (20 mg ml À 1 ; Figure 4c , open dots). This interaction was specific to PspC as treatment with anti-PspC IgG did not alter adherence of D39 DPspC (Figure 4d , gray dots). Internalization of D39 was inhibited by anti-PspC IgG (Figure 4e, gray dots) but not by purified total IgG (open squares).
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