Author: Chow, Ken Yan Ching; Hon, Chung Chau; Hui, Raymond Kin Hi; Wong, Raymond Tsz Yeung; Yip, Chi Wai; Zeng, Fanya; Leung, Frederick Chi Ching
Title: Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) Document date: 2016_11_28
ID: xuj4yymz_51
Snippet: The assay based on the presence of SARS-CoV antibodies is suggested to be valid only for specimens obtained more than three weeks after the onset of fever (88 , 89 ) , although some patients have detectable SARS-CoV antibodies within 14 days of the onset of illness. Nevertheless, the negative result, i.e. absence of SARS-CoV antibodies, within the first three weeks cannot conclude that the patient is free of the virus, though the ELISA method was.....
Document: The assay based on the presence of SARS-CoV antibodies is suggested to be valid only for specimens obtained more than three weeks after the onset of fever (88 , 89 ) , although some patients have detectable SARS-CoV antibodies within 14 days of the onset of illness. Nevertheless, the negative result, i.e. absence of SARS-CoV antibodies, within the first three weeks cannot conclude that the patient is free of the virus, though the ELISA method was still defined as a good standard for rapid diagnosis of SARS (85 ) . Seroconversion from negative to positive or a four-fold rise in antibody titer from acute to convalescent serum indicates recent infection (http://www.who.int/csr/sars/diagnostictests/en/).
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